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KMID : 1140120110160010013
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Cancer Prevention Research
2011 Volume.16 No. 1 p.13 ~ p.18
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Plasma Selenium Concentrations in the Benign or Malignant Gynecological Tumors - A Pilot Study in the Korean Women -
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Kim Seung-Jo
Kim Soo-Hyun
Lee Chan
Jung Sang-Geun
Lee Sun-Young
Chung An-Sik
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Abstract
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The aim of this study was to determine levels of plasma selenium (Se) concentration in gynecological cancer patients and to find a possibility of useful supplemental marker to differentiate benign and malignant disease and also to prevent the development of carcinogenesis. Atotal of 136 patients between 18 and 75 ages were divided into five groups depending on the stage of their cancer Group 1 exibited benign tumors, and groups 2∼5 were diagnosed to have malignant tumors with four subgroups such as pre-invasive cervical lesion, early stage cancer, advanced stage cancer and recurrent cancer, respectively. Selenium concentrations in blood plasma (μg/l) of group 1, 2, 3, 4, and 5 were 93.9±14.1, 92.6±55.9, 89.2±`14.1, 80.7±?14.8 and 73.7±?10.5, respectively. The Se concentrations of advanced and recurrent cancer patients were significantly lower compared with those of benign and pre-invasive cervical cancer patients. There was no difference in Se concentration between benign tumor and pre-invasive cervical cancer patient groups. The Se concentrations of invasive cervical patients were significantly lower than those of pre-invasive lesion patients. The trend of plasma Se levels was decreased proportionately with severity of tumor stages from benign to malignancy and recurrence.
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KEYWORD
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Selenium, Benign tumor, Gynecologic cancer
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